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U583
 Equipe
1
Génétique et thérapie des cécités
rétiniennes
Equipe 2
Physiopathologie et thérapies de l’oreille
interne
Equipe 3
Neurobiologie cellulaire et moléculaire du système
somato-sensoriel
Equipe 4
Physiologie et approches thérapeutiques des pathologies médullaires
Equipe
5
Physiologie et thérapie des désordres vestibulaires
U844
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Position: PhD in
Signal Processing, Assistant Professor, University
of Montpellier1
Academic and research
Track :
Jérôme Bourien began its research activity
in 1999 in the “Laboratoire Traitement du Signal
et de l’Image” (LTSI) at the University
of Rennes (France). During five years, he developed
signal processing and statistical methods for the analysis
of interictal EEG signals from epileptic patients.
In 2004, he joined the Computational NeuroEngineering
Laboratory (CNEL) at the University of Florida (USA)
directed by the Pr José Principe. During this
period, he worked on the detection of synchronized
firings in multivariate neural spike trains during
motor tasks. In 2005, he obtained an assistant professor
position at the “research center for hearing
aids” at the University of Montpellier (France)
where he teaches signal processing and electronic.
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Research
interests :
The present research program of Jérôme
Bourien is focused on the cochlear neurotransmission
mechanisms and their links with the occurrence of tinnitus
in human and in animal models. The auditory nerve fibres
exhibit a spontaneous (basal) firing activity in the
absence of acoustic stimulations. Alterations of this
firing rate may explain several types of tinnitus,
named peripheral tinnitus.
- The first aim of its research is to explain, with
statistical methods, how the spontaneous activity
is modified in animals experiencing tinnitus. To
deal with this question, he analyses single-unit
spontaneous activity in animal models of tinnitus.
- The second aim concerns the modelling of the spontaneous
activity. He is developing a phenomenological model
of the inner-hair-cell and its synaptic complex with
the auditory-nerve taking into account the NMDA receptors
and the gain-control feedback loop exerted by the
lateral olivocochlear efferents fibres.
The long term objective of its research is to propose
a diagnostic tool for peripheral tinnitus in human.
Methods : spikes and
burst detection, renewal processes analysis, neural
spike train analysis and modelling, inner-hair-cell
and auditory-nerve synapse complex modelling
Key words : glutamate,
AMPA & NMDA
receptors, synaptic transmission, lateral olivocochlear
efferents, inner ear, tinnitus.
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Selected
publications :
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Bourien J., Ruel J., Senhadji L., Puel J.L. Comparison
of three spike detectors dedicated to single unit
action potentials of the auditory nerve. 29th
IEEE EMBS Annual International Conference, Lyon,
23-26 Août 2007.
Bourien J., Sanchez J., Bellanger J.J., Wendling
F., Principe J. Detection of synchronized firings
in multivariate neural spike trains during motor
tasks. 29th IEEE EMBS Annual International
Conference, Lyon, 23-26 Août 2007.
Bourien J., Bellanger J.J., Bartolomei F., Chauvel
P., Wendling F., Mining reproducible activation
patterns in epileptic intracerebral EEG Signals
: application to interictal activity, IEEE
Trans Biomed Eng, 2004; 51: 304-15.
Bourien J., Bartolomei F., Bellanger J.J., Gavaret
M., Chauvel P., Wendling F, A method to identify
reproducible subsets of co-activated structures
during interictal spikes. Application to intracerebral
EEG in temporal lobe epilepsy. Clin Neurophysiol.
2005 Feb;116(2):443-55.
Wendling F., Bartolomei F., Bellanger J.J., Bourien
J., Chauvel P., Epileptic fast intracerebral EEG
activity: evidence for spatial decorrelation at
seizure onset, Brain, 2003, 126(6):1449-59.
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