Institut des Neurosciences de Montpellier : Physiologie et physiopathologie de l’oreille interne

U583

Equipe 1
Génétique et thérapie des cécités rétiniennes

Equipe 2
Physiopathologie et thérapies de l’oreille interne

Equipe 3
Neurobiologie cellulaire et moléculaire du système somato-sensoriel

Equipe 4
Physiologie et approches thérapeutiques des pathologies médullaires

Equipe 5
Physiologie et thérapie des désordres vestibulaires

U844

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Michel Eybalin

Position: Research Director II, INSERM

Academic and scientific Track :

I entered in fall 1978 the Sensory Neurophysiology Laboratory headed by Prof. Rémy Pujol at the University of Provence in Marseilles to localize candidate cochlear neurotransmitters using autoradiography. In 1982, I defended my PhD thesis on the "Morphological Approach of the Cochlear Neurotransmitters". After a post-doc stay at the Inserm-Cnrs Center of Immunology of Marseilles-Luminy, I joined the new Inserm U254 research unit created by Prof. Rémy Pujol in Montpellier to work on the electron microscopic immunolocalization of efferent cochlear neurotransmitters. I was appointed as an Inserm Researcher in 1984. In 1987, I defended my Doctorat ès Sciences (HDR) on "The Neuroactive Substances of the Cochlear Efferent Systems". Since my arrival in the Inserm U254 up to the late nineties, I headed a research team in the Inserm unit dedicated to the localization and the pharmacological characterization of cochlear neurotransmitters. In 2003, with the members of the former U254 unit, I joined the Institute of Neurosciences of Montpellier (INM-Inserm U583) to work in the “Physiology and Therapy of the Inner Ear” team, headed by Prof. Jean-Luc Puel. Since 2005, I also have in charge the Electron Microscopy facility of the Montpellier 1 University.

Main achievements :

- Provide neuroanatomical evidence for a glutamatergic nature of cochlear sensory inner hair cells.
- Provide electron microscopic localization of olivocochlear (efferent) neurotransmitters.
- Identify colocalisation pattern of efferent neurotransmitters.
- Show regulation of proteins of the inner hair cell synapse (vesicular proteins, receptor subunits) at the onset of hearing.
- Publication of >65 papers in international journal (h‑index : 27).
- Member of the Editorial Board of Audiology & Neurotology.
- Head of the Electron Microscopy facility of the Montpellier 1 University.

Research interests :

My research interest is focused on the mechanisms of the inner hair cell glutamatergic neurotransmission, its regulation by lateral olivocochlear (efferent) neurotransmitters and the consequences of the dysfunctions of this hair cell synapse and its regulation.
This implies: (1) working on an hair cell synapse which tonically releases glutamate, identifying proteins involved in this release and in the glutamate effects, (2) determining the balance between inhibitory and excitatory effects in the lateral efferent regulation of the hair cell synapse, (3) identify the part played by the inner hair cell synapse in the generation of tinnitus and deafness.

Selected publications :

Eybalin M, Caicedo A, Renard N, Ruel J, Puel JL. Transient Ca2+-permeable AMPA receptors in postnatal rat primary auditory neurons. Eur J Neurosci 2004, 20: 2981-2989.

Eybalin M, Aure F, Renard N, Safieddine S. Cysteine-string protein in inner hair cells of the organ of Corti: synaptic expression and upregulation at the onset of hearing. Eur J Neurosci 2002, 15: 1409-1420.

Ruel J, Nouvian R, Gervais d'Aldin C, Pujol R, Eybalin M, Puel JL. Tonic dopamine inhibition of the auditory nerve activity in the adult mammalian cochlea. Eur J Neurosci 2001, 14: 977-986.

Safieddine S, Soto Prior AM, Eybalin M. Choline acetyltransferase, glutamate decarboxylase, tyrosine hydroxylase, calcitonin gene-related peptide and opioid peptides coexist in lateral efferent neurons of rat and guinea pig. Eur J Neurosci 1997, 9: 356-367.

Puel JL, Pujol R, Tribillac F, Ladrech S, Eybalin M. Protective effects of glutamate antagonists upon ischemia-induced neurotoxicity in the guinea pig cochlea. J Comp Neurol 1994, 341: 241-256.

Eybalin M. Neurotransmitters and neuromodulators of the mammalian cochlea. Physiol Rev 1993, 73: 309-373.

Puel JL, Pujol R, Ladrech S, Eybalin M. Alpha-amino-3-hydroxy-5-methyl-4-isoxazole proprionic acid (AMPA) electrophysiological and neurotoxical effects in the guinea pig cochlea. Neuroscience 1991, 45: 63-72.

Eybalin M, Parnaud C, Geffard M, Pujol R. Immunoelectron microscopy identifies several types of GABA-containing efferent synapses in the guinea pig organ of Corti. Neuroscience 1988, 24: 29-38.

Eybalin M, Pujol R. Choline acetyltransferase (ChAT) immunoelectron microscopy distinguishes at least three types of efferent synapses in the organ of Corti. Exp Brain Res 1987, 65: 261-270.

Eybalin M, Pujol R. A radioautographic study of [3H] L-glutamate and [3H] L-glutamine uptake in the guinea pig cochlea. Neuroscience 1983, 9: 863-871.

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