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U583
Equipe
1
Génétique et thérapie des cécités
rétiniennes
Equipe 2
Physiopathologie et thérapies de l’oreille
interne
Equipe 3
Neurobiologie cellulaire et moléculaire du système
somato-sensoriel
Equipe 4
Physiologie et approches thérapeutiques des pathologies médullaires
Equipe
5
Physiologie et thérapie des désordres vestibulaires
U844
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Position: PhD,
Assistant Professor of Neurobiology of Hearing, University
of Montpellier I, Faculty of Medicine.
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Research
interests :
Tonic dopamine inhibition
by the lateral olivocochlear (LOC) efferents acts
as a permanent gain control at the initialization site
of the action potential to maintain the functional
and morphological integrity of the primary auditory
neurons. Removal of this tonic inhibition results in
the development of early signs of excitotoxicity. LOC
system may maintain the adequate firing of the auditory
nerve fibers and protect them against glutamate receptor
overstimulation occurring under physiopathological
conditions such as ischemia or acoustic trauma.
Techniques: functional
model of cochlear slices ex vivo, gross cochlear
and auditory nerve single unit recordings coupled with
multiple intracochlear perfusions in vivo.
Key words: glutamate,
excitotoxicity, cochlear AMPA & NMDA receptors,
synaptic transmission, dopamine modulation, lateral
olivocochlear efferents, inner ear, tinnitus.

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Selected
publications :
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C.G. d’Aldin, J. Ruel, R. Assié, R.
Pujol, J.L. Puel (1997). Implication of NMDA
type glutamate receptors in neural regeneration and
neoformation of synapses after excitotoxic injury
in the guinea pig cochlea. International Journal
of Developmental Neuroscience,
15: 619-629.
J.L. Puel, J. Ruel, C.G. d’Aldin, R. Pujol
(1998). Excitotoxicity and repair of cochlear
synapses after noise-trauma induced hearing loss. NeuroReport,
9: 2109-2114.
J. Ruel, C. Chen, R. Pujol, R.P. Bobbin, J.L.
Puel (1999). AMPA-preferring glutamate receptors
in cochlear physiology of adult guinea pig. Journal
of Physiology (London), 518: 667-680.
J. Ruel, R.P. Bobbin, D. Vidal, R. Pujol, J.L.
Puel (2000). The selective AMPA receptor
antagonist GYKI 53784 blocks action potential generation
and excitotoxicity in the guinea pig cochlea. Neuropharmacology,
39: 1959-1973.
J. Ruel, R. Nouvian, C. Gervais d’Aldin,
R. Pujol, M. Eybalin, J.L. Puel (2001). Dopamine
inhibition of the auditory nerve activity in the
adult mammalian cochlea. European
Journal of Neuroscience, 14:
977-986.
J.L. Puel, J. Ruel, M. Guitton, J. Wang, R. Pujol
(2002). The inner hair cell synaptic complex:
physiology, pharmacology and new therapeutic strategies. Audiology & Neuro-Otology, 7:
49-54.
J. Ruel, M.J. Guitton, J.L. Puel (2002). Negative
allosteric modulation of AMPA-preferring receptors
by the selective isomer GYKI 53784 (LY303070), a
specific non-competitive AMPA antagonist. CNS
Drug Reviews, 8: 235-254.
G. Rebillard, J. Ruel, R. Nouvian, H. Saleh, R.
Pujol, Y. Dehnes, J. Raymond, J.L. Puel, G. Devau
(2003). Glutamate transporters in the guinea
pig cochlea: partial mRNA sequences, cellular expression
and functional implications. European
Journal of Neuroscience, 17:83-92.
M.J. Guitton., J. Caston, J. Ruel, R.M. Johnson,
R. Pujol, J.L. Puel (2003). Salicylate induces
tinnitus through activation of cochlear NMDA receptors. Journal
of Neuroscience, 23:3944-3952.
R. Nouvian, J. Ruel, J. Wang, M.J. Guitton, R.
Pujol, J.L. Puel (2003). Degeneration of
sensory outer hair cells following pharmacological
blockade of cochlear KCNQ channels in the adult
guinea pig. European Journal of Neuroscience,
17: 2553-2562.
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S. Boyer, J. Ruel, J.L. Puel, C. Chabbert (2004).
A procedure to label inner ear afferent nerve endings
for calcium imaging. Brain Res. Protoc.,
13:91-8.
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B. Delprat, J. Ruel, M.J. Guitton, G. Hamard,
M. Lenoir, R. Pujol, J.L. Puel, P. Brabet, C.P.
Hamel (2005). Deafness and cochlear fibrocyte alterations
in mice deficient for the inner ear protein otospiralin. Molecular
Cellular Biology, 25:847-53.
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J. Ruel, J. Wang, R. Pujol, A. Hameg, M. Dib,
J.L. Puel (2005). Neuroprotective effect of riluzole
in acute noise-induced hearing loss. NeuroReport,
13;16:1087-90.
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J. Ruel, J. Wang, D. Demêmes, S. Gobaille,
J.L. Puel, G. Rebillard (2006). Dopamine transporter
is essential for the maintenance of spontaneous
activity of auditory nerve neurons and their responsiveness
to sound stimulation. Journal of Neurochemistry,
97: 190-200.
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F. Venail, J. Wang, J. Ruel, E. Ballana, G. Rebillard,
M. Eybalin, M. Arbones, A. Bosch, J.L. Puel (2007).
Coxsackie adenovirus receptor and anb3/anb5integrins
in adenovirus gene transfer of rat cochlea. Gene
Therapy, 14: 30-37.
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J. Ruel, J. Wang, G. Rebillard, M. Eybalin, R.
Lloyd, R. Pujol, J.L. Puel (2007). Physiology,
pharmacology and plasticity at the inner hair cell
synaptic complex. Hearing Research,
227: 19-27.
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J. Wang, J. Ruel, S. Ladrech, C. Bonny, T. R.
Van De Water, J.L. Puel (2007). Inhibition of the
JNK-mediated mitochondrial cell death pathway restores
auditory function in sound exposed animals. Molecular
Pharmacology, 71: 654-666.
Selected international communications :
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J. Ruel, A. Caicedo, R. Pujol, J.L. Puel. Modulation
of desensitization at AMPA versus kainate receptors
by cyclothiazide and concanavalin A in cochlear
physiology. Association
for Research in Otolaryngology (ARO), St Petersburg Beach,
Florida, (USA), February 15-19, 1998.
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J. Ruel, C. d’Aldin, R. Pujol, J.L. Puel.
Dopamine modulates excitatory neurotransmission
in the guinea pig cochlea. Association
for Research in Otolaryngology (ARO),
St Petersburg Beach, Florida, (USA), February 13-18,
1999.
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J. Ruel, R. Nouvian, R.P. Bobbin, R. Pujol, J.L.
Puel. Effect of the selective non-competitive
AMPA receptor antagonist GYKI 53784 on cochlear
physiology and excitotoxicity in the guinea pig
cochlea. Association
for Research in Otolaryngology (ARO), St Petersburg Beach, Florida, (USA),
February 20-24, 2000.
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J. Ruel, J.L. Puel, M. Guitton, J. Wang, R. Pujol.
The inner hair cell synaptic complex: physiology,
pharmacology and new therapeutic strategies. “Auditory
Function and Dysfunction: Molecular and Physiological
Mechanisms” Satellite Meeting. Auckland
(New Zealand), August 19-22, 2001.
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J. Ruel, G. Rebillard, D. Dememes,
S. Gobaille, J. Wang, J.L. Puel. Localization and
function of dopamine transporter in the mammalian
cochlea. Association
for Research in Otolaryngology (ARO), Baltimore,
(USA), February 5-9, 2006.
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J. Ruel, R. Nouvian, G. Rebillard,
M. Eybalin, J.L. Puel. Dual function of the lateral
olivocochlear efferent pathway in the mammalian
cochlea. Association
for Research in Otolaryngology (ARO),
Denver Colorado, (USA), February 10-15, 2007.
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