Institut des Neurosciences de Montpellier : Physiologie et physiopathologie de l’oreille interne

U583

Equipe 1
Génétique et thérapie des cécités rétiniennes

Equipe 2
Physiopathologie et thérapies de l’oreille interne

Equipe 3
Neurobiologie cellulaire et moléculaire du système somato-sensoriel

Equipe 4
Physiologie et approches thérapeutiques des pathologies médullaires

Equipe 5
Physiologie et thérapie des désordres vestibulaires

U844

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Jérôme Ruel

Position: PhD, Assistant Professor of Neurobiology of Hearing, University of Montpellier I, Faculty of Medicine.

Research interests :

Tonic dopamine inhibition by the lateral olivocochlear (LOC) efferents acts as a permanent gain control at the initialization site of the action potential to maintain the functional and morphological integrity of the primary auditory neurons. Removal of this tonic inhibition results in the development of early signs of excitotoxicity. LOC system may maintain the adequate firing of the auditory nerve fibers and protect them against glutamate receptor overstimulation occurring under physiopathological conditions such as ischemia or acoustic trauma.

Techniques: functional model of cochlear slices ex vivo, gross cochlear and auditory nerve single unit recordings coupled with multiple intracochlear perfusions in vivo.

Key words: glutamate, excitotoxicity, cochlear AMPA & NMDA receptors, synaptic transmission, dopamine modulation, lateral olivocochlear efferents, inner ear, tinnitus.

Selected publications :

C.G. d’Aldin, J. Ruel, R. Assié, R. Pujol, J.L. Puel (1997). Implication of NMDA type glutamate receptors in neural regeneration and neoformation of synapses after excitotoxic injury in the guinea pig cochlea. International Journal of Developmental Neuroscience, 15: 619-629.

J.L. Puel, J. Ruel, C.G. d’Aldin, R. Pujol (1998). Excitotoxicity and repair of cochlear synapses after noise-trauma induced hearing loss. NeuroReport, 9: 2109-2114.

J. Ruel, C. Chen, R. Pujol, R.P. Bobbin, J.L. Puel (1999). AMPA-preferring glutamate receptors in cochlear physiology of adult guinea pig. Journal of Physiology (London), 518: 667-680.

J. Ruel, R.P. Bobbin, D. Vidal, R. Pujol, J.L. Puel (2000). The selective AMPA receptor antagonist GYKI 53784 blocks action potential generation and excitotoxicity in the guinea pig cochlea. Neuropharmacology, 39: 1959-1973.

J. Ruel, R. Nouvian, C. Gervais d’Aldin, R. Pujol, M. Eybalin, J.L. Puel (2001). Dopamine inhibition of the auditory nerve activity in the adult mammalian cochlea. European Journal of Neuroscience, 14: 977-986.

J.L. Puel, J. Ruel, M. Guitton, J. Wang, R. Pujol (2002). The inner hair cell synaptic complex: physiology, pharmacology and new therapeutic strategies. Audiology & Neuro-Otology, 7: 49-54.

J. Ruel, M.J. Guitton, J.L. Puel (2002). Negative allosteric modulation of AMPA-preferring receptors by the selective isomer GYKI 53784 (LY303070), a specific non-competitive AMPA antagonist. CNS Drug Reviews, 8: 235-254.

G. Rebillard, J. Ruel, R. Nouvian, H. Saleh, R. Pujol, Y. Dehnes, J. Raymond, J.L. Puel, G. Devau (2003). Glutamate transporters in the guinea pig cochlea: partial mRNA sequences, cellular expression and functional implications. European Journal of Neuroscience, 17:83-92.

M.J. Guitton., J. Caston, J. Ruel, R.M. Johnson, R. Pujol, J.L. Puel (2003). Salicylate induces tinnitus through activation of cochlear NMDA receptors. Journal of Neuroscience, 23:3944-3952.

R. Nouvian, J. Ruel, J. Wang, M.J. Guitton, R. Pujol, J.L. Puel (2003). Degeneration of sensory outer hair cells following pharmacological blockade of cochlear KCNQ channels in the adult guinea pig. European Journal of Neuroscience, 17: 2553-2562.
S. Boyer, J. Ruel, J.L. Puel, C. Chabbert (2004). A procedure to label inner ear afferent nerve endings for calcium imaging. Brain Res. Protoc., 13:91-8.
B. Delprat, J. Ruel, M.J. Guitton, G. Hamard, M. Lenoir, R. Pujol, J.L. Puel, P. Brabet, C.P. Hamel (2005). Deafness and cochlear fibrocyte alterations in mice deficient for the inner ear protein otospiralin. Molecular Cellular Biology, 25:847-53.
J. Ruel, J. Wang, R. Pujol, A. Hameg, M. Dib, J.L. Puel (2005). Neuroprotective effect of riluzole in acute noise-induced hearing loss. NeuroReport, 13;16:1087-90.
J. Ruel, J. Wang, D. Demêmes, S. Gobaille, J.L. Puel, G. Rebillard (2006). Dopamine transporter is essential for the maintenance of spontaneous activity of auditory nerve neurons and their responsiveness to sound stimulation. Journal of Neurochemistry, 97: 190-200.
F. Venail, J. Wang, J. Ruel, E. Ballana, G. Rebillard, M. Eybalin, M. Arbones, A. Bosch, J.L. Puel (2007). Coxsackie adenovirus receptor and anb3/anb5integrins in adenovirus gene transfer of rat cochlea. Gene Therapy, 14: 30-37.
J. Ruel, J. Wang, G. Rebillard, M. Eybalin, R. Lloyd, R. Pujol, J.L. Puel (2007). Physiology, pharmacology and plasticity at the inner hair cell synaptic complex. Hearing Research, 227: 19-27.
J. Wang, J. Ruel, S. Ladrech, C. Bonny, T. R. Van De Water, J.L. Puel (2007). Inhibition of the JNK-mediated mitochondrial cell death pathway restores auditory function in sound exposed animals. Molecular Pharmacology, 71: 654-666.

Selected international communications :

J. Ruel, A. Caicedo, R. Pujol, J.L. Puel. Modulation of desensitization at AMPA versus kainate receptors by cyclothiazide and concanavalin A in cochlear physiology. Association for Research in Otolaryngology (ARO), St Petersburg Beach, Florida, (USA), February 15-19, 1998.
J. Ruel, C. d’Aldin, R. Pujol, J.L. Puel. Dopamine modulates excitatory neurotransmission in the guinea pig cochlea. Association for Research in Otolaryngology (ARO), St Petersburg Beach, Florida, (USA), February 13-18, 1999.
J. Ruel, R. Nouvian, R.P. Bobbin, R. Pujol, J.L. Puel. Effect of the selective non-competitive AMPA receptor antagonist GYKI 53784 on cochlear physiology and excitotoxicity in the guinea pig cochlea. Association for Research in Otolaryngology (ARO), St Petersburg Beach, Florida, (USA), February 20-24, 2000.
J. Ruel, J.L. Puel, M. Guitton, J. Wang, R. Pujol. The inner hair cell synaptic complex: physiology, pharmacology and new therapeutic strategies. “Auditory Function and Dysfunction: Molecular and Physiological Mechanisms” Satellite Meeting. Auckland (New Zealand), August 19-22, 2001.
J. Ruel, G. Rebillard, D. Dememes, S. Gobaille, J. Wang, J.L. Puel. Localization and function of dopamine transporter in the mammalian cochlea. Association for Research in Otolaryngology (ARO), Baltimore, (USA), February 5-9, 2006.
J. Ruel, R. Nouvian, G. Rebillard, M. Eybalin, J.L. Puel. Dual function of the lateral olivocochlear efferent pathway in the mammalian cochlea. Association for Research in Otolaryngology (ARO), Denver Colorado, (USA), February 10-15, 2007.

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