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Name : Christian
Chabbert
Research Interests
:
My research activity is mainly focused on the characterization
of molecular mechanisms that control the setting of the vestibular
sensory information and its transmission towards the brain
stem. By combining molecular approaches (electrophysiology,
two-photon imaging, single cell RTPCR) with in vivo diagnostics
of the vestibular function (behaviour testing of the vestibular
function in rodents), my main objectives are 1/ to identify
new pharmacological targets for the control of the vestibular
sensory information, 2/ to develop new strategies to protect
vestibular primary neurons following impairment of the sensori
organs, and repair synaptic contacts between sensory cells
and their cognate nerve fibres, 3/ to bring new insights into
the understanding of mechanisms that regulates the endolymph
ionic homeostasis, 4/ to study the potentialities to transplant
vestibular organs for the rehabilitation of vestibular function.
Main achievements
:
- Creation and coordination of the Research Group on
Vestibular Disorders at the Montpellier Institute for Neuroscience
since 2006 (http://www.inmfrance.com/1_equipe2_chabbert.php)
- Member of the Groupe d’Etude des Vertiges (GEV)
- President of the organising comity of the 17th Ionic Channel
Meeting 17-20 September 2006.
(http://congres.igh.cnrs.fr/canaux-ioniques/index2006.htm)
- First demonstration that variations of the primary stimulus
during development directly affect the electrophysiological
properties of the vestibular sensory cells (collaboration
with the French Space Agency - CNES (Chabbert et al. 2003a;
Brugeaud et al. 2006)
- First demonstration that neonate vestibular hair cells transiently
acquire a sodium-based excitability and the ability to release
BDNF during synaptogenesis (Chabbert et al. 2003b).
- Demonstration that adult vestibular hair cells may recall
the developmental sodium-based excitability and the ability
to release BDNF following synapse impairment (Brugeaud et
al. 2007).
- Setting of the first method to visualize cytosolic calcium
events associated with neurotransmission at inner ear neurons
terminals using two-photon microscopy (Boyer et al. 2004)
- Morphophysiological identification of the glutamate receptors
involved in neurotransmission at the vestibular calyx synapse
(Bonsacquet et al. 2005).
- Development of vestibular sensory organ cultures in mammals
and method to measure K+ secretion in the endolymph.
- Setting of behaviour tests of vestibular function in rodents
at the INM (since May 2005).
Main publications
:
Chabbert C, Chambard J. M., Sans A, and Desmadryl G.
Three types of depolarization-activated potassium currents
in acutely isolated mouse vestibular neurons. Journal of Neurophysiology
(2001) 85: 1017-1026.
Chabbert C, Chambard J. M., Valmier J., Sans A, and Desmadryl
G. Hyperpolarisation-activated (Ih) current in mouse vestibular
primary neurons. Neuroreport (2001) 12 : 2701-2704.
Chabbert C, Brugeaud, Lennan G, Lehouelleur J and Sans A.
Electrophysiological properties of the utricular primary transducer
are modified during development under hypergravity. European
Journal of Neurosciences (2003a) 17: 1-4.
Chabbert C, I Mechaly, V Sieso, P Giraud, A Brugeaud, J Lehouelleur,
F Couraud, J Valmier, A Sans. Voltage-gated Na+ channels activation
regulates both action potential and BDNF release in rat utricular
hair cells during a restricted period of development. The
Journal of Physiology London (2003b) 553:113-123.
Boyer S, Ruel J, Puel JL, Chabbert C. A detailed procedure
to label inner ear afferent terminals for calcium imaging.
Brain Research Protocol (2004) 13: 91-98.
Mechaly I, Scamps F, Chabbert C, Couraud F, Sans A and Valmier
J. Molecular diversity of voltage-gated sodium channels alpha
subunits expressed in neuronal and non-neuronal excitable
cells. Neuroscience (2005) 130 (2): 389-396.
Gaboyard S, Chabbert C, Travo C, Bancel F, Lehouelleur J,
Sans A. Three dimensional culture of newborn rat utricle with
extracellular matrix: A new functional in vitro model. Neuroscience
(2005) 133: 253-265.
Bonsacquet J, Brugeaud A, Compan V, Desmadryl G, Chabbert
C. AMPA type glutamate receptor mediates neurotransmission
at turtle vestibular calyx synapse. Journal of Physiology
London (2006) 576: 63-71.
Brugeaud A, Gaboyard S, Puel JL, Chabbert C. Development under
modified gravity affects the transient excitability of mammal
vestibular hair cells. Neuroreport (2006) 17: 1697-1701.
Brugeaud A, Travo C, Dememes D, Lenoir M, Llorens J, Puel
JL, Chabbert C. Control of hair cell excitability by vestibular
primary sensory neurons. Journal of Neuroscience (2007) in
press.
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