| Patrick
Carroll |
 |
Function
:
Researcher, CNRS.
Career :
- Ph.D. Genetics Dept. Trinity College,
Dublin Ireland.
- Post-doc and Staff Scientist: Max-Planck
Institute for Psychiatry, Munich, Germany.
- Researcher, CNRS. INSERM U.382, Marseille
France. INSERM
U.583 Montpellier France.
Main achievements
:
Cloning and functional analysis of cilary
neurotrophic factor (CNTF).
Creation and functional analysis of mice mutant for BDNF
(brain-derived neurotrophic factor) (Max-Planck Institute,
Munich, Germany)
Identification of genes expressed in sub-populations of motoneurons.
Elucidation of the role of the ECM molecule reelin in the
migration of hindbrain motoneuron sub-types (INSERM U.382,
Marseille, France)
Research interests
:
Development and connectivity of the somatosensory
neurons of the dorsal root ganglia (DRG). The DRG contains
a functionally diverse population of neurons that are sensitive
to temperature, painful stimuli, touch and muscle contraction.
A functional genomics approach using SAGE banks was employed
to identify genes expressed in sensory neuron sub-types during
development and after peripheral nerve traumatism. The functions
of selected genes in various aspects of sensory neuron development
such as specification, axon growth, peripheral and central
connectivity as well as in their responses to traumatism
are being studied using transgenic mice technology, transfection
of cultured sensory neurons with plasmids and siRNA, transfection
in vivo by intrathecal injection.
Selected publications
:
Bourane
S, Garces
A, Venteo S, Pattyn A, Hubert T, Fichard
A, Puech S, Boukhaddaoui H, Baudet C, Takahashi S, Valmier
J and Carroll P (2009). Low-threshold mechanoreceptor subtypes
selectively express MafA and are specified by Ret signalling. Neuron (sous
presse).
Ohayon
D, Pattyn
A, Venteo S, Valmier J, Carroll P and Garces
A. (2009) Zfh1 prevents apoptosis of a peripheral glia sub-type by
antagonizing a JNK-depednent pathway. EMBO J.
2009 Oct 21;28(20):3228-43. Epub 2009 Sep 10.
Bourane
S, Mechaly I, Venteo S, Garces A, Fichard A, Valmier J
and Carroll P (2007)
A SAGE-based screen for genes expressed in sub-populations
of neurons in the mouse dorsal root ganglion. BMC
Neurosci. 2007 Nov 19;8(1):97
Mechaly
I, Bourane S, Piquemal D, Al-Jumaily M, Venteo S, Puech
S, Scamps F, Valmier J and Carroll P(2006)
Gene profiling during development and after a peripheral
nerve traumatism reveals genes specifically induced by
injury in dorsal root ganglia. Mol.
Cell. Neurosci. 32:217−29.
Rossel
M, Loulier K, Feuillet C, Alonso S and Carroll P (2005) Reelin
signaling is necessary for a specific step in the migration
of hindbrain efferent neurons. Development,
132;1175-1185.
Dubreuil
AS, Boukhaddaoui H, Desmadryl G, Martinez-Salgado C, Lewin
G, Carroll P, Valmier J and Scamps F (2004). Role
of T-type calcium current in identified D-hair mechanoreceptor
neurons studied in vitro. J. Neurosci.
24:8480-8484
Hack
I., Bancila M., Loulier K., Carroll P. and Cremer
H. (2002) “Reelin is a detachment
signal in tangential chain migration during postnatal neurogenesis”. Nature neuroscience 5
: 939-45
Carroll
P*, Lewin
GR*, Koltzenburg* M, Toyka KV and Thoenen, H. (1998). “A
role for BDNF in mechanosensation". Nature Neuroscience 1;42-46.
* Equal contribution.
Hack
I., Bancila M., Loulier K., Carroll P. and Cremer
H. (2002) “Reelin is a detachment
signal in tangential chain migration during postnatal neurogenesis”. Nature neuroscience 5
: 939-45
Carroll,
P., Gayet,
O., Feuillet, C., Kallenbach, S., de Bovis, B., Dudley,
K. and Alonso, S. (2001) Juxtaposition
of CNR protocadherins and reelin expression in the developing
spinal cord. Mol. Cell.
Neurosci. 17
: 611-23.
Korte*
M, Carroll* P, Wolf E, Brem G, Thoenen H and Bonhoeffer
T (1995). "Hippocampal
long-term potentiation is impaired in mice lacking brain-derived
neurotrophic factor". Proc. Nat. Acad. Sci., 92:8856-8860.
* Equal contribution.
Sendtner
M, Schmalbruch H, Stöckli KA, Carroll P, Kreutzberg
GW, and Thoenen H (1992) "Ciliary neurotrophic factor
prevents degeneration of motorneurons in mouse mutant progressive
motor neuropathy". Nature, 358:502-504.
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