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Function
:
Researcher, CNRS.
Career :
- Ph.D. Genetics Dept. Trinity College,
Dublin Ireland.
- Post-doc and Staff Scientist: Max-Planck
Institute for Psychiatry, Munich, Germany.
- Researcher, CNRS. INSERM U.382, Marseille
France. INSERM
U.583 Montpellier France.
Main achievements
:
Cloning and functional analysis of cilary
neurotrophic factor (CNTF).
Creation and functional analysis of mice mutant for BDNF
(brain-derived neurotrophic factor) (Max-Planck Institute,
Munich, Germany)
Identification of genes expressed in sub-populations of motoneurons.
Elucidation of the role of the ECM molecule reelin in the
migration of hindbrain motoneuron sub-types (INSERM U.382,
Marseille, France)
Research interests
:
Development and physiopathology of the somatosensory neurons
of the dorsal root ganglia (DRG). The DRG contains a functionally
diverse population of neurons that are sensitive to temperature,
painful stimuli, touch and muscle contraction. A functional
genomics approach using SAGE banks was employed to identify
genes expressed in sensory neuron sub-types during development
and after peripheral nerve traumatism. The functions of selected
genes in various aspects of sensory neuron development such
as specification, axon growth, peripheral and central connectivity
as well as in their responses to traumatism are being studied
using transgenic mice technology, transfection of cultured
sensory neurons with plasmids and siRNA, transfection in
vivo by intrathecal injection.
Selected publications
:
Bourane
S, Mechaly I, Venteo S, Garces A, Fichard A, Valmier J
and Carroll P (2007)
A SAGE-based screen for genes expressed in sub-populations
of neurons in the mouse dorsal root ganglion. BMC
Neurosci. 2007 Nov 19;8(1):97
Mechaly
I, Bourane S, Piquemal D, Al-Jumaily M, Venteo S, Puech
S, Scamps F, Valmier J and Carroll P(2006)
Gene profiling during development and after a peripheral
nerve traumatism reveals genes specifically induced by
injury in dorsal root ganglia. Mol.
Cell. Neurosci. 32:217−29.
Rossel
M, Loulier K, Feuillet C, Alonso S and Carroll P (2005) Reelin
signaling is necessary for a specific step in the migration
of hindbrain efferent neurons. Development,
132;1175-1185.
Dubreuil
AS, Boukhaddaoui H, Desmadryl G, Martinez-Salgado C, Lewin
G, Carroll P, Valmier J and Scamps F (2004). Role
of T-type calcium current in identified D-hair mechanoreceptor
neurons studied in vitro. J. Neurosci.
24:8480-8484
Hack
I., Bancila M., Loulier K., Carroll P. and Cremer
H. (2002) “Reelin is a detachment
signal in tangential chain migration during postnatal neurogenesis”. Nature neuroscience 5
: 939-45
Carroll
P*, Lewin
GR*, Koltzenburg* M, Toyka KV and Thoenen, H. (1998). “A
role for BDNF in mechanosensation". Nature Neuroscience 1;42-46.
* Equal contribution.
Hack
I., Bancila M., Loulier K., Carroll P. and Cremer
H. (2002) “Reelin is a detachment
signal in tangential chain migration during postnatal neurogenesis”. Nature neuroscience 5
: 939-45
Carroll,
P., Gayet,
O., Feuillet, C., Kallenbach, S., de Bovis, B., Dudley,
K. and Alonso, S. (2001) Juxtaposition
of CNR protocadherins and reelin expression in the developing
spinal cord. Mol. Cell.
Neurosci. 17
: 611-23.
Korte*
M, Carroll* P, Wolf E, Brem G, Thoenen H and Bonhoeffer
T (1995). "Hippocampal
long-term potentiation is impaired in mice lacking brain-derived
neurotrophic factor". Proc. Nat. Acad. Sci., 92:8856-8860.
* Equal contribution.
Sendtner
M, Schmalbruch H, Stöckli KA, Carroll P, Kreutzberg
GW, and Thoenen H (1992) "Ciliary neurotrophic factor
prevents degeneration of motorneurons in mouse mutant progressive
motor neuropathy". Nature, 358:502-504.
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