| Jean
Valmier |
 |
Function
:
MD, PhD, Psychiatrist, Professor of Neurosciences at University
Montpellier II, director of the INM team “molecular
and cellular neurobiology of the somato-sensory system”.
Academic and research
track :
Jean Valmier started his scientific career in 1982, as clinician,
in the Neurological Department of Montpellier in the Pr M.
Baldy-Moulinier’s clinical laboratory. Working on the
functional activity of the normal and epileptic human brain,
he become MD in 1983, PhD, psychiatrist and senior lecturer
in 1989. Concomitantly, he spent his post-doctoral fellowship
(2 years) at Gif sur Yvette CNRS Institute in the laboratory
of L. Tauc where he worked, using patch-clamp technique,
on neuronal functional activity at cellular and molecular
level. In 1999, he joined both the INSERM unity U432 (director
Pr A. Sans) and the University Montpellier II where he become
professor in Neurosciences. He developed a new thematic concerning
the development and the pathology of the somato-sensory system
and actively participated with Christian Hamel, Alain
Privat and Jean–Luc Puel to the creation of the Institute
of Neurosciences of Montpellier (INM) and of the INSERM unit
entitled “Pathophysiology and Therapy of Sensory and
motor defects” (INSERM U583) where he manages the INSERM
team “Molecular and cellular neurobiology of the somato-sensory
system”.
Main achievements
:
-
Characterization of functional interactions between neurotrophic
factors and ionic channels regulating neuronal development
before synaptogenesis
-
Identification of immunological channelopathies in human
developing brain
-
Actually his group characterizes
new mechanism for regenerative growth and identifies
new molecular markers that specify and control sensory
modalities.
Research interests
:
- Which are genetic and epigenetic events that control
somato-sensory system development?
- To characterize the molecules and mechanisms that underlie
the normal functioning (transduction, transmission and
integration) of the different sensory modalities, especially
mechano and proprioception, during adulthood and aging
- To understand the mechanisms that come into play in
post-traumatic neuropathies, causes of neuropathic pain
conditions and sensori-motor dysfunction (sensory ataxia).
Selected publications
(2000-2007) :
Scamps F., Vigues S., Restituito S., Campo
B., Roig A., Charnet P., Valmier J. Sarco-endoplasmic
ATPase Blocker 2,5-Di(tert-butyl)-1,4-benzohydroquinone Inhibits
N-,P-, and Q- but Not T-, L-, or R-Type Calcium Currents
in Central and Peripheral Neurons. (2000) Molecular
Pharmacology, 58,18-26.
Boukhaddaoui H., Sieso V., Scamps F., Valmier J. An
activity-dependent NT-3 autocrine loop regulates the phenotype
of developing hippocampal pyramidal neurons before target
contact. (2001) J. Neurosci., 15,
21(22), 8789-8797.
Andre S., Boukhaddaoui H., Campo B., Al-Jumaily M., Mayeux
V., Greuet D., Valmier J., Scamps F. Axotomy-induced
expression of calcium-activated chloride current in subpopulations
of mouse dorsal root ganglion neurons. (2003) J.
Neurophysiol .,90, 3764-73.
Dubreuil AS., Boukhaddaoui H., Desmadryl G., Martinez-Salgado
C., Moshourab R., Lewin GR., Carroll P., Valmier J., Scamps
F. (2004). Role of T-type calcium current in identified D-hair
mechanoreceptor neurons studied in vitro. J.
Neuroscience 24: 8480-8484.
Hilaire C, Campo B, Andre S, Valmier J, Scamps F (2005)
K+ current regulates calcium-activated
chloride current-induced afterdepolarization in axotomized
sensory neurons. Eur
J Neurosci: Sep;22(5):1073-80.
Mechaly, I., Bourane, S., Piquemal, D., Al-Jumaily, M., Venteo,
S., Puech, S., Scamps, F., Valmier, J., Carroll, P. (2006). "Gene
profiling during development and after a peripheral nerve
traumatism reveals genes specifically induced by injury in
dorsal root ganglia." Mol
Cell Neurosci. 32,
217-229.
Pieraut S., Matha V., Sar C., Hubert T., Méchaly I.,
Hilaire C., Mersel M., Delpire E., Valmier J., Scamps F.
NKCC1 Phosphorylation Stimulates
Neurite Growth of Injured Adult Sensory Neurons Running title :
NKCC1 and regenerative growth. J. Neurosci. (2007) 27,
6751-6759.
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