2.2 Molecular basis of age-related hearing loss

Age-related hearing loss or presbycusis is a major health problem. Cumulative effects of aging on hearing are exacerbated by genetic and environmental factors such as noise or drug exposure. Here, we are using multi-disciplinary approaches to decipher the mechanisms of presbycusis and to develop therapies against hearing loss at elderly.


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Using molecular and cellular biology together with biochemistry, we aim at understand signaling pathways underlying the cochlear neuro-epithelium senescence. Pharmacological or genetic rescue is then applied for prevent the hearing loss in age-related hearing loss models.

 

 

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Scanning electron microscopy of the cochlea. Hair bundle of the sensory hair cell are conspicuous. (A) shows three rows of outer hair cell and one row of inner hair cells. (B) outer hair cell stereociliary bundle magnification. In the age-related hearing loss animal model, hair cells degenerate (B and C).



Major publications

Menardo et al., Antioxid Redox Signal., 18, 2011
Wang et al., Mol Pharmacol., 71:654-666, 2007
Ladrech et al., Eur J Neurosci., 26:2922-2930, 2007
Wang et al., Neuropharmacology., 52:1426-1437, 2007
Wang et al., Cancer Res., 64:9217-9224, 2004

Collaborations

  • Edwin Rubel (Washington University, USA)
  • Pierre Rustin (Université Paris 7)
  • Pierre Carayon (SANOFI, Montpellier)

Fundings

  Fondation Avenir   Audisan

Contact

Jing Wang