Motoneuron Disease: Neuroinflammation and Therapy
Our mission is to 1) understand how the cellular environment contributes to the degeneration of motoneurons in amyotrophic lateral sclerosis (ALS) and other motoneuron disorders and 2) develop new therapeutic strategies.
Our research is carried out by a multidisciplinary team of neurobiologists, electrophysiologists, immunologists, clinicians, and geneticists.
Reactive astrocytes in the vicinity of motoneurons play a pivotal role during the pathogenic process by releasing factors selectively toxic for motoneurons. We propose an interdisciplinary approach to investigate the astrocytic determinants of motoneuron degeneration.
2. Neuroimmunity in the physiopathology of ALS
Neuroimmunity, a pathological signature of ALS, is characterized by the accumulation of blood-derived immune cells in the central nervous system (CNS). Our current research efforts focus on 1) elucidating the molecular and cellular basis of the neuroimmune response in ALS and 2) developing innovative therapeutic approaches.
3. Electrical activity in motoneuron diseases
Sensory abnormalities and increased excitability of motoneurons have been reported in ALS and spinal muscular atrophy. Our research efforts are directed to investigate the molecular determinants of aberrant electrical activity of motoneurons in the disease
4. Clinical and genetic aspects of neuroinflammation
Our goal is to integrate the knowledge gained by basic research in a translational perspective. Our research focus on the completion of our preclinical investigations by studies of human biological specimens and genetic association.