Neuroplasticity

1. Functional neuro-plasticity and glial tumors

 

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We have demonstrated in the past years that proliferation and invasion of slow-growing lesion such as diffuse low-grade glioma elicited functional brain reshaping, explaining why the patients with this kind of tumor had no or only slight neurological deficit, at least at time of diagnosis (made in more than 80% of cases because of inaugural seizures). Therefore, human brain plastic potential in adults was underestimated in the classical literature.

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2. Neural Stem Cells

 

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The adult nervous system harbours a pool of neural stem and progenitor cells which are disseminated in the parenchyma or located in particular regions called niches. These cells have the capacity to self-renew extensively or to differentiate into glial and neuronal cells.  Neural stem cell niches have a complex organisation which allows stem cells to receive adequate molecular cues to maintain them in an immature state.

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3. New targets and therapeutical molecules against gliomas

 

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Our team operates at the interface of chemistry and biology and pursues therapeutic innovation by identifying new anti-cancer targets as well as the development of new therapeutic compounds. At the present we focus on two families of compounds: the oxysterols, 7β-hydroxycholesterol in particular, and the phostines, a new family of compounds developed by our research consortium. These compounds are tested for antitumor activity and their mechanism of action is studied in glioma in vitro and in vivo models. Our final objective is to promote the clinical and industrial transfer of these compounds.

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