Presentation of the Institute

The Institute for Neurosciences of Montpellier (INM) is located in the Neuroscience (Head and Neck) hospital, close to the University Campus.

   

The INM houses 200 people working on vision, hearing, somatosensory wiring, and myelination. Molecular to systems level investigations are carried-out through core technical facilities, which are opened to academic and private users outside the INM. Team competences cover expertise in genetic, molecular and cellular biology, electrophysiology, computational neurosciences pre-clinical and clinical researches. Research outputs favor the development of new treatments for sensory and motor deficits, with a strong interest in inherited retinal and optic blindness, auditory neuropathies, neurodegenerative diseases (amyotrophic lateral sclerosis, giant axonal neuropathy), somatosensation disorders (touch and pain) and glial pathologies (gliomas and Charcot Marie Tooth disease).

 

Relevant Publications (2009-2015)

Bouilloux et al., Loss of the transcription factor Meis1 prevents sympathetic neurons target-field innervation and increases susceptibility to sudden cardiac death. Elife. 2016 Feb 8;5. pii: e11627.

   

Guillet et al., Actin Filaments Regulate Exocytosis at the Hair Cell Ribbon Synapse. J Neurosci. 2016 Jan 20;36(3):649-54.

   

Herbet et al., The dorsal cingulate cortex as a critical gateway in the network supporting conscious awareness. Brain.  2015 Dec 30. pii: awv381.

   

Angebault et al., Recessive. Mutations in RTN4IP1 Cause Isolated and Syndromic Optic Neuropathies. Am J Hum Genet. 2015 Nov 5;97(5):754-60.

   

Bowerman et al., Tweak regulates astrogliosis, microgliosis and skeletal muscle atrophy in a mouse model of amyotrophic lateral sclerosis. Hum Mol Genet. 2015 Jun 15;24(12):3440-56.

   

Ohayon et al., Zeb family members and boundary cap cells underlie developmental plasticity of sensory nociceptive neurons.  Dev Cell. 2015 May 4;33(3):343-50.

   

Parsadaniantz et al., Opioid and chemokine receptor crosstalk: a promising target for pain therapy? Nat Rev Neurosci. 2015 Feb;16(2):69-78.

   

Guichet et al., Notch1 stimulation induces a vascularization switch with pericyte-like cell differentiation of glioblastoma stem cells. Stem Cells 2015 Jan;33(1):21-34.

   

Meunier et al., Frequency and clinical pattern of vitelliform macular dystrophy caused by mutations of interphotoreceptor matrix IMPG1 and IMPG2 genes. Ophthalmology 2014 Dec;121(12):2406-14.

   

Otsmane et al., Somatic and axonal LIGHT signaling elicit degenerative and regenerative responses in motoneurons, respectively. EMBO Rep. 2014, 15(5):540-7.

   

Sendin et al., Spatiotemporal pattern of action potential firing in developing inner hair cells of the mouse cochlea. Proc Natl Acad Sci U S A. 2014, 111(5):1999-2004.

   

Gonzalez et al., In vivo introduction of transgenes into mouse sciatic nerve cells in situ using viral vectors. Nat Protoc. 2014, 9(5):1160-9.